Category: Technical Publications

In this 2019 paper, Crommelin et al. discuss the changing landscape of biologics and pharmaceutical formulation, analytical methods, immunogenicity and quality control. They specifically discuss the technology behind ParticleSentryᴬᴵ and acknowledge the promise our approach demonstrates. The paper acknowledges the …

Therapeutic proteins are exposed to stress during the manufacturing process and can aggregate to form particles. These protein aggregate particles can induce adverse immune responses in patients. This paper discusses the use of image compression techniques proven in facial recognition …

Compendial methods for the analysis of subvisible particles in protein drugs are inadequate. New techniques, like flow-imaging microscopy (FIM), show promise but require subjective, qualitative manual identification. These manual methods ignore relevant structural or morphological information embedded in the images. …